You've beaten cancer. You've taken care of your family financially for the forseeable future. You've rescued Jesse (Aaron Paul), your "business" partner from an abyss of drug addiction and depression and set him up in a cushy recovery situation.
You've managed to evade law enforcement. This includes a dogged DEA bigwig who just so happens to be your brother-in-law who is actually looking for you (well your alias "Heisenberg" - named after a pioneer in quantum mechanics).
And most importantly you're still alive when so many that you've come into contact with are no longer.
Donald (John de Lancie, who was the comic antagoinst "Q" from Star Trek: TNG) - the grief-stricken air traffic controller who can't come to grips with his daughter's overdose, which yields tragic results.
I guess we'll see ya'll next season. It's a break that will seem too long.